The new SARS-CoV-2 variant Omicron (B.1.1.529) was first identified in South Africa at the end of November 2021 and classified as a variant of concern (VOC). Omicron has led to increased COVID-19 cases in South Africa and has been detected in Australia, Germany, the Netherlands, Canada, and many other countries. Following the quick rise of the Delta variant, Omicron’s emergence is concerning scientists due to the impressive number of mutations, many of which are found within the Spike protein (~ 30 mutations). The increased number of mutations in Spike’s receptor-binding domain (RBD) may affect how this variant interacts with the entry receptor ACE2 and antibodies. Much remains to be learned about Omicron, but preliminary findings suggest an increased risk of reinfection with this VOC.
Spike protein mutations in the new SARS-CoV-2 variant
of
concern, Omicron.
Retrieved from COG-UK/Mutation Explorer. Creative Commons Attribution-
4.0 International License.
Mutations in the SARS-CoV-2 variant Omicron. Retrieved from SARS-CoV-2 variant genome viewer, Stanford University Coronavirus Antiviral & Resistance Database.
Cat. No. | Plasmid Name | Description | Price | Timeline | Ordering |
---|---|---|---|---|---|
MC_0101271 | SARS-CoV-2 Omicron Strain S gene original_pUC57 | SARS-CoV-2 Omicron Strain | $420 | Next-day | Submit Request |
MC_0101272 | SARS-CoV-2 Omicron Strain S gene Human codon_pUC57 | SARS-CoV-2 Omicron Strain | $420 | Next-day | Submit Request |
MC_0101273 | SARS-CoV-2 Omicron Strain S gene original_pcDNA3.1(+) | SARS-CoV-2 Omicron Strain | $420 | Next-day | Submit Request |
MC_0101274 | SARS-CoV-2 Omicron Strain S gene Human codon_pcDNA3.1(+) | SARS-CoV-2 Omicron Strain | $420 | Next-day | Submit Request |
Please click this page for more S protein plasmids.
All peptide libraries are designed by overlapping peptide library tool.
Protein Name | Source | Number of Peptide | Purity | Sequence | Timeline | Ordering |
---|---|---|---|---|---|---|
SARS-CoV-2 Spike Glycoprotein (B.1.1.529) | SARSr-CoV (Severe Acute Respiratory Syndrome-related coronavirus 2) Spike glycoprotein (B.1.1.529) | 315 peptides (15mers with 11 aa overlap) | Crude | Datasheet | In stock | RP30221 Omicron BA.2 |
Crude | Datasheet | In stock | RP30121 | |||
90% | Datasheet | In stock | RP30219 | |||
≥70% to ≥98% | 3 weeks |
Submit Request or email us at [email protected] |
Sublineage | Cat. No. | Protein Name | Mutation Site | Tag | Ordering |
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BA.1 | Z03729 | S1 Protein | A67V, del69-70, T95I, G142D, del143-145, del211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H | C-terminal His | Order Now |
Z03728 | S-RBD | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | C-terminal His | Order Now | |
Z03730 | RBD-HRP | G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H | C-terminal His | Order Now | |
Z03731 | N Protein | G204R, R203K | C-terminal His | Order Now | |
BA.2 | Z03741 | RBD-HRP | G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H | C-terminal His | Order Now |
For other variants, tags, or expression system, please click here for off-the-shelf products or click here for custom services.
Cat. No. | Clone | Wild-type NP binding | Delta NP binding | Omicron NP binding | Antibody Pair | LFA Assay |
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A02135 | N338 | +++++ | +++++ | +++++ | A02135-A02136 A02135-A02138 |
+++++ |
A02136 | N34 | +++++ | ++++++ | ++++++ | A02135-A02136 | ++++++ |
A02137 | N66 | ++++++ | +++++ | ++++++ | Not Test | Not Test |
A02138 | Cocktail | +++++ | +++++ | ++++++ | A02135-A02138 | ++++ |
Cat. No. | Description | Recommend Applications |
---|---|---|
A02161 | SARS-CoV-2 (Omicron) Neutralizing Antibody Standard | Calibrate quantitative assay of SARS-CoV-2 neutralizing antibody (sVNT, PRNT, pVNT) for the Omicron variant |
Amount | Titer | Timeline | Ordering |
---|---|---|---|
0.1mL, 0.5mL, 1mL, and others | 108 IFU/ml | 4-6 weeks (including shipping) |
On-demand only Email us at [email protected] |
Cat. No. | Product Name | Mutation Site | Components | Timeline | Ordering |
---|---|---|---|---|---|
SC2087-027 | SARS-CoV-2 CoV-2 Omicron Variant (B.1.1.529) Pseudovirus Neutralization Assay Kit_Luc Reporter | H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
|
4-6 Weeks | Email us at [email protected] |
Cat. No. | Product Name | Description | Variant Research Use | Timeline | Ordering |
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L00847-A | SARS-CoV-2 Surrogate Neutralizing Test (sVNT) Kit Visit this page to learn more about this kit. |
A blocking ELISA that mimics the gold standard cell-based assay, PRNT, to qualitatively and semi-quantitatively detect functional neutralizing antibodies against SARS-CoV-2. | Use GenScript’s Variant of Concern (VOC) RBD-HRP products in place of the WT-based RBD-HRP kit component. | In stock | Submit Request |