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Scientists studied the effect of very low calorie diet (VLCD) in combatting diabetes. The data showed that in a rat model, VLCD-induced pleiotropic mechanisms reverse hyperglycemia, reduced hepatic insulin resistance, glycogenolysis, and acetyl-CoA content among other indicators.
Perry et al.Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes Nov 9, 2017, DOI: 10.1096/fj.201601323RR
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