Mammalian synthetic biology has the potential to revolutionise the treatment of hard-to-tackle diseases by reprogramming cells with synthetic devices. To obtain robust and specific activity, synthetic circuits must sense and respond to the intracellular or extracellular environment, recognizing the unhealthy condition.
This NATURE WEBCAST will focus on the design of a platform that can be easily readapted to sense intracellular proteins of interest, and applications for engineering potential cell-based therapies. The speaker will describe work on RNA-encoded circuits that use RNA-binding proteins, siRNAs and proteases to engineer sensors, cascade and switches, and will present recent research to address one of the standing bottlenecks of mammalian synthetic biology: the burden that synthetic circuits impose to the cells by competition for intracellular resources.
You will learn:
- How to engineer cells to deliver a therapeutic output only when needed
- How to engineer RNA-encoded programs
- Issues to address to speed development of new synbio-based therapies