Bacterial infections can be life-threatening. With increasing numbers of antibiotic-resistant bacteria, there is a desperate need for new infection control approaches. A recently published study identified a new approach in treating antibiotic-resistant bacterial infections.
In this study, the authors tested the antibiotic activity of a membrane-active lipopeptide, C10OOc12O, and found that it sensitized gram-negative bacilli (GNB) to host antibacterial proteins and various antibiotics both in vivo and in vitro. Noticeably, in mice subjected to antibiotic-resistant bacterial infections, 100% of the mice injected with a placebo or traditional antibiotic did not survive, whereas C10OOc12O alone increased the survival rate of mice to 40%. In combination with a traditional antibiotic, C10OOc12O treatment increased the survival rate to 60%. Overall, this study suggested a new approaching to treating antibiotic-resistant bacterial infections by using a lipopeptide on its own or in combination with other antibiotics.
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