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Scientists at the Tisch Cancer Institute developed an immunotherapy based on intra-tumor administration of Flt3L and the oncolytic Newcastle Disease Virus (NDV) to improve recruiting and activating dendritic cells.
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Learn how investigators at George Washington University Cancer Center leveraged synthetic peptides to activate and amplify patient-derived T cells to generate specific T cell immunotherapies for medulloblastoma.
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uncovering-immunogenic-peptides-of-clinical-significance-in-crispr-cas9
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SARS-CoV-2 vaccines have reduced efficiency against variants of concern. Find out how antibody and T cell responses are affected by variant associated mutations.
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Learn about how vaccine or infection-induced T cell responses against the original SARS-CoV-2 strain remain protective against new variants.
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Learn about a new approach to the treatment of Parkinson's disease alpha-synuclein pathology that uses a cell-penetrating peptide to induce proteasome degradation of alpha-synuclein.
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Non-Coding Sequences Expand Neoantigens for Therapy
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How the Proteasome Modulates the Immunopeptidome
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α-Hemolysin derived from Staphylococcus aureus Promotes Inflammation Resolution through Generation of Specialized Pro-resolving Mediators
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Peptide libraries allow investigators to identify epitopes inducing T cell activation which may be used in the design of vaccines to treat infectious diseases such as COVID.