Enabling Non-Viral T Cell Engineering with ssDNA HDR Templates
Nov 13, 2022

News

Enabling Non-Viral T Cell Engineering with ssDNA HDR Templates

The success of cancer immunotherapies, such as CAR T cells for targeting tumor cells in hematological malignancies, has spurred an unprecedented push to develop more and improved living drugs.

CRISPR/Cas9 Based Screens Advancing Cell Therapies
Jul 04, 2022

News

CRISPR/Cas9 Based Screens Advancing Cell Therapies

Learn how CRISPR screens, such as knock-out, knock-in, CRISPRa, and CRISPRi, are helping to identify molecular factors and programs critical for developing effective cell therapies.

Tackling Tumor Relapse with More Sensitive Engineered T Cells
Jun 06, 2022

News

Tackling Tumor Relapse with More Sensitive Engineered T Cells

Learn how a new T cell receptor, HIT, engineered by Dr. Michel Sadelain’s group achieves greater sensitivity for tumor antigens than CARs.

Saving Crops from Powdery Mildew with CRISPR/Cas9 Gene Editing
Mar 15, 2022

Resource

Saving Crops from Powdery Mildew with CRISPR/Cas9 Gene Editing

Learn how CRISPR/Cas9 editing tools support precise mlo gene editing to develop plant varieties resistant to common fungal diseases such as powdery mildew while retaining growth potential and productivity.

Improving CRISPR/Cas9 Genome Editing with Single-Stranded DNA Payloads
Feb 25, 2022

Resource

Improving CRISPR/Cas9 Genome Editing with Single-Stranded DNA Payloads

CRISPR/Cas9 enables targeted genomic insertions, clearing the way for precise therapies for cancer, rare diseases, and more.

CRISPRing T Cell Therapeutics: What Are The Benefits?
Dec 14, 2021

Resource

CRISPRing T Cell Therapeutics: What Are The Benefits?

Learn about the benefits of recently developed CRISPR/Cas tools for engineering T cell therapeutics, including precise modifications, ready-to-use T cell medicines, and improved T cell performance.

CRISPR/Cas9 Based Preclinical Advances for Amyotrophic Lateral Sclerosis
Oct 10, 2021

News

CRISPR/Cas9 Based Preclinical Advances for Amyotrophic Lateral Sclerosis

Learn how CRISPR/Cas9 editing tools have been leveraged to target the SOD1 gene in a mouse model of ALS, preventing the development of ALS pathology.

 CRISPR/Cas9 Editing: T Cell Engineering for Immunotherapies
Jul 06, 2021

News

CRISPR/Cas9 Editing: T Cell Engineering for Immunotherapies

Learn about CRISPR/Cas9-based non-viral knockin for T cell engineering and how the Marson lab at UCSF is optimizing these methods to support T cell therapies.

CRISPR/Cas13: Evolving Biomedical Applications
Jun 21, 2021

News

CRISPR/Cas13: Evolving Biomedical Applications

Learn about advances using CRISPR/Cas13 nucleases in viral detection and treatment, including influenza A and SARS-CoV-2.

Single-Stranded DNA for Improved Knockin Efficiency: Animal Model Generation
Mar 17, 2021

Resource

Single-Stranded DNA for Improved Knockin Efficiency: Animal Model Generation

Learn how long stranded DNA (lssDNA) donor templates facilitates knockin CRISPR/Cas9 editing efficiency for animal model generation.

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