Molecular Biology News

Three Advancing Gene Therapy Strategies for ALS

Learn how scientists at the University of Pennsylvania are leveraging the strengths of IVT mRNA-LNPs to develop an effective vaccine against Borrelia burgdorferi, the Lyme disease causing bacteria.

The “Promising Novel Antitumor Strategies in Early Phase Clinical Trials” session at AACR2023 highlighted progress in evaluating new immunotherapy strategies targeting solid tumor antigens.

Learn how work presented at ACCR2023 is leveraging IVT mRNA to improve existing cancer immunotherapies or develop new therapy strategies by arming myeloid cells with CARs.

Reducing genetic code redundancy through genetic compression, sense codon replacement, deletion of corresponding tRNAs, and genetic code swapping have emerged as innovative ways to induce viral resistance.

A new outer membrane vesicle-based vaccine platform offers a simpler approach to antigen display by leveraging the expression of a Synthetic Antigen-Binding Protein (SNAP) to easily enable the docking of various biotinylated antigens.

Learn how scientists at the Pritzker School of Molecular Engineering, University of Chicago, have engineered a masked Interleukin-12 protein that is preferentially unmasked at tumor sites, thereby reducing adverse events commonly associated with systemic

Learn about molecular mechanisms underscoring Dystroglycanopathies, a type of muscular dystrophy, and a new AAV-based gene replacement strategy to restore muscle function and reduce pathology.

Learn about NAFLD and NASH chronic liver disease states and how an AAV8 delivered E06-scfv helps reduce pathogenesis by targeting oxidized phospholipids.

Learn how scientists at the University of Pennsylvania and Moderna are advancing the production and delivery of effective mRNA therapeutics.