From “Cold” to “Hot” Tumors with Masked Interleukin-12
Oct 18, 2022

News

From “Cold” to “Hot” Tumors with Masked Interleukin-12

Learn how scientists at the Pritzker School of Molecular Engineering, University of Chicago, have engineered a masked Interleukin-12 protein that is preferentially unmasked at tumor sites, thereby reducing adverse events commonly associated with systemic

Restoring Muscle Function in Muscular Dystrophy with AAV-Large1
Sep 27, 2022

News

Restoring Muscle Function in Muscular Dystrophy with AAV-Large1

Learn about molecular mechanisms underscoring Dystroglycanopathies, a type of muscular dystrophy, and a new AAV-based gene replacement strategy to restore muscle function and reduce pathology.

Preventing Progression of Hepatic Steatosis to Fibrosis with an AAV-Based Gene Strategy
Sep 13, 2022

News

Preventing Progression of Hepatic Steatosis to Fibrosis with an AAV-Based Gene Strategy

Learn about NAFLD and NASH chronic liver disease states and how an AAV8 delivered E06-scfv helps reduce pathogenesis by targeting oxidized phospholipids.

Advances Supporting IVT mRNA Medicines
Jul 18, 2022

News

Advances Supporting IVT mRNA Medicines

Learn how scientists at the University of Pennsylvania and Moderna are advancing the production and delivery of effective mRNA therapeutics.

Boosting CAR-T cells with mRNA Vaccines: New Immunotherapy Strategy
May 25, 2022

News

Boosting CAR-T cells with mRNA Vaccines: New Immunotherapy Strategy

Learn how a new Claudin 6 CAR T immunotherapy strategy leverages a Claudin6 mRNA nanoparticle vaccine to boost the efficacy of cell therapy against solid tumors.

Advancing Cell Therapies for Duchene Muscular Dystrophy
Apr 25, 2022

Resource

Advancing Cell Therapies for Duchene Muscular Dystrophy

Learn about a new cell therapy strategy under clinical evaluation that leverages Cardiosphere-derived cells (CDCs) to reduce the progression of cardiac and skeletal myopathy in DMD patients.

Advancing mRNA Medicines: Progressing Beyond Vaccines to Immunotherapies
Feb 17, 2022

Resource

Advancing mRNA Medicines: Progressing Beyond Vaccines to Immunotherapies

Advancing mRNA Medicines: Progressing Beyond Vaccines to Immunotherapies

Sanger Sequencing vs. Next-Generation Sequencing (NGS)
Dec 30, 2021

News

Sanger Sequencing vs. Next-Generation Sequencing (NGS)

NGS has reduced cost and accelerated DNA sequencing, but Sanger sequencing continues to be ideal for routine low volume synthetic DNA and plasmid sequencing.

GenScript Expands Gene Synthesis Manufacturing Capabilities in the USA
Nov 30, 2021

Blog

GenScript Expands Gene Synthesis Manufacturing Capabilities in the USA

Learn about GenScript’s manufacturing facility in the USA, which will offer fully automated gene synthesis and sequencing services.

Sequencing Analysis to Enable Precise Pediatric Cancer Therapies
Sep 26, 2021

News

Sequencing Analysis to Enable Precise Pediatric Cancer Therapies

At St. Jude Children’s Hospital, scientists used an integrated sequencing platform to understand genomic variants associated with a broad range of pediatric cancer types.

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