Overview

Bispecific antibodies (bsAbs) are transforming drug discovery by targeting two different antigens at once, leading to potential breakthroughs in treatment effectiveness. Despite their potential, producing bsAbs is a challenging task: it requires complex designs to maintain high binding affinity for both antigens and a tailored production process that ensures the correct assembly of antibody components, all while achieving a pure and stable final product. At GenScript, we provide our customers with a seamless bsAb production experience, from micrograms to grams, through our advanced approaches.

70+

Different Formats of BsAb Produced

5,000+

BsAb Projects Delivered

10+

Years in BsAb Expression

Highlights

Specialized format design

AI-driven codon optimization

Optimized plasmid ratio

Optimized production process

Proprietary TurboCHO™ cell line

Multi-step purification strategy

Production Insights

Bispecific antibody formats can be categorized by asymmetry, symmetry, and fragment. The choice of bsAb format depends on the specific therapeutic goals, target antigens, and desired pharmacokinetic and pharmacodynamic properties. Each format offers unique advantages and considerations in terms of engineering, manufacturing, and clinical applications.

Click the below Interactive Production Map to see our production insights for 70+ different formats. We rate each format by its manufacturability score and indicate the recommended purification steps and expected yield.

1 CrossMabCH1-CL

Manufacturability
Score 1-5 according to bsAb’s expression level and purification difficulty defined by GenScript
(e.g. score 1 represents the most difficult)
2
Recommend purification step(s) 2 steps
Typical yield
Low: <50mg /L
Moderate: 50 – 200mg/L
High: >200mg/L
High

Example of our Interactive Production Map

Choose the Service for Your Bi-specific Antibody Projects

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with TurboCHO™ Bi-specific Antibody Expression

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