Current efforts at reprogramming T cells for therapeutic purposes rely on using recombinant viral vectors. Unfortunately, viral vectors do not target transgenes to specific genomic sites. Moreover, the manufacturing and testing of effective viral vectors is often a lengthy and expensive process, which slows research progress and clinical use. However, recent studies have shown that re-engineering T cells in a specific and efficient manner is possible using homology-directed repair (HDR).
Theo Roth
Marson Lab, UCSF
Theodore Roth, MD/PhD student, Marson Lab, UCSF. Graduated from Stanford with a BS in Biology and an MS in Biomedical Informatics. Currently, under MD and PhD training at UCSF, with interest in Immunology, Genetics, Informatics, and Genome Editing in the context of Cellular Therapeutics.
Reprogramming human T
cell function and specificity with non-viral genome targeting
Roth TL,
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