The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
The human BAX gene is shown in the context of the human genome below. To see information about the BAX gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse BAX, rat BAX, and human BAX, as well as on-demand BAX ORF clones in 183 other species.
GenEZ™ ORF CDNA Clones make it easy to order customized expression-ready ORF clones from the world's largest commercial ORF clone database.
