CBL gene (Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase)
Do you need CBL gene to express the CBL protein for functional or characterization studies? Get the CBL gene in an expression-ready vector for your molecular biology studies by ordering a CBL ORF clone.
About the CBL gene
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
Genomic context of CBL gene
The human CBL gene is shown in the context of the human genome below. To see information about the CBL gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse CBL, rat CBL, and human CBL, as well as on-demand CBL ORF clones in 183 other species.
Genomic sequence of CBL gene
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