FGFR2 gene (Fibroblast Growth Factor Receptor 2)
Do you need FGFR2 gene to express the FGFR2 protein for functional or characterization studies? Get the FGFR2 gene in an expression-ready vector for your molecular biology studies by ordering a FGFR2 ORF clone.
About the FGFR2 gene
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Genomic context of FGFR2 gene
The human FGFR2 gene is shown in the context of the human genome below. To see information about the FGFR2 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse FGFR2, rat FGFR2, and human FGFR2, as well as on-demand FGFR2 ORF clones in 183 other species.
Genomic sequence of FGFR2 gene
GenEZ™ ORF cDNA clones
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