FGFR3 gene (Fibroblast Growth Factor Receptor 3)
Do you need the FGFR3 gene to express the FGFR3 protein for functional or characterization studies? Get the FGFR3 gene in an expression-ready vector for your molecular biology studies by ordering a FGFR3 ORF clone.
About the FGFR3 gene
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
Genomic context of FGFR3 gene
The human FGFR3 gene is shown in the context of the human genome below. To see information about the FGFR3 gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse FGFR3, rat FGFR3, and human FGFR3, as well as on-demand FGFR3 ORF clones in 183 other species.
Genomic sequence of FGFR3 gene
GenEZ™ ORF cDNA clones
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