This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
The human FLT3 gene is shown in the context of the human genome below. To see information about the FLT3 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse FLT3, rat FLT3, and human FLT3, as well as on-demand FLT3 ORF clones in 183 other species.
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