This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
The human KRAS gene is shown in the context of the human genome below. To see information about the KRAS gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse KRAS, rat KRAS, and human KRAS, as well as on-demand KRAS ORF clones in 183 other species.
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