This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
The human MDM2 gene is shown in the context of the human genome below. To see information about the MDM2 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MDM2, rat MDM2, and human MDM2, as well as on-demand MDM2 ORF clones in 183 other species.
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