This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
The human MSH2 gene is shown in the context of the human genome below. To see information about the MSH2 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MSH2, rat MSH2, and human MSH2, as well as on-demand MSH2 ORF clones in 183 other species.
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