MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
The human MYBPC3 gene is shown in the context of the human genome below. To see information about the MYBPC3 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MYBPC3, rat MYBPC3, and human MYBPC3, as well as on-demand MYBPC3 ORF clones in 183 other species.
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