This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
The human PDGFRA gene is shown in the context of the human genome below. To see information about the PDGFRA gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse PDGFRA, rat PDGFRA, and human PDGFRA, as well as on-demand PDGFRA ORF clones in 183 other species.
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