The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
The human RB1 gene is shown in the context of the human genome below. To see information about the RB1 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse RB1, rat RB1, and human RB1, as well as on-demand RB1 ORF clones in 183 other species.
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