This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
The human REST gene is shown in the context of the human genome below. To see information about the REST gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse REST, rat REST, and human REST, as well as on-demand REST ORF clones in 183 other species.
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