The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
The human SOD1 gene is shown in the context of the human genome below. To see information about the SOD1 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse SOD1, rat SOD1, and human SOD1, as well as on-demand SOD1 ORF clones in 183 other species.
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