The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
The human SP1 gene is shown in the context of the human genome below. To see information about the SP1 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse SP1, rat SP1, and human SP1, as well as on-demand SP1 ORF clones in 183 other species.
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