This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
The human TP53 gene is shown in the context of the human genome below. To see information about the TP53 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse TP53, rat TP53, and human TP53, as well as on-demand TP53 ORF clones in 183 other species.
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