This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
The human CDH1 gene is shown in the context of the human genome below. To see information about the CDH1 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse CDH1, rat CDH1, and human CDH1, as well as on-demand CDH1 ORF clones in 183 other species.
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