Do you need DMD gene to express the DMD protein for functional or characterization studies? Get the DMD gene in an expression-ready vector for your molecular biology studies by ordering a DMD ORF clone.
The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
The human DMD gene is shown in the context of the human genome below. To see information about the DMD gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse DMD, rat DMD, and human DMD, as well as on-demand DMD ORF clones in 183 other species.
GenEZ™ ORF cDNA clones make it easy to order customized expression-ready ORF clones from the world's largest commercial ORF clone database.
