The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The human MET gene is shown in the context of the human genome below. To see information about the MET gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MET, rat MET, and human MET, as well as on-demand MET ORF clones in 183 other species.
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