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Preparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha

Bioengineered. 2021-12; 
Xinmei Liao, Hui Liang, Jian Pan, Qian Zhang, Jiaqi Niu, Cuili Xue, Jian Ni, Daxiang Cui
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Proteins, Expression, Isolation and Analysis … 27]. ExpressPlus™ PAGE Gel and running buffer were purchased from Genscript Biotech Corporation (M42015C, M00138, Nanjing, China). Reducing … Get A Quote


Tumor necrosis factor alpha (TNFα) is an important inflammatory factor. It plays a cardinal role in inflammatory synovitis and articular matrix degradation, and is, therefore, a prime target for directed immunotherapy in autoimmune diseases. In this study, we screened and isolated the B cells secreting anti-TNFα antibody from patients with rheumatoid arthritis. The heavy-chain and light-chain sequences of the antibody were cloned and used to generate a stable Chinese hamster ovary (CHO) cell line producing the antibody, which was named Haidalimumab. Haidalimumab showed a TNFα binding affinity comparable to that of the antibody Humira, which is the best TNF inhibitor on the market. Furthermore, Haidalimumab c... More


Fully human monoclonal antibody, affinity, inhibitor, rheumatoid arthritis, tumor necrosis factor α