Webinars » CRISPR Disease Applications

Applications of CRISPR-Cas9 for disease research

The ability to sequence and edit DNA is fundamental to understanding the role of genetic elements in normal biology and disease. A microbial adaptive immune system, CRISPR-Cas9, was recently repurposed to enable the precise editing of the mammalian genome. This has not only simplified and expanded genome editing applications but has reduced the cost and speed at which model organisms can be generated. To further the potential of this technology for biomedical research we have established a CRISPR-Cas9 knockin mouse and demonstrated its potential for in vivo gene editing by viral- and non-viral-mediated delivery of guide RNA into neurons, pneumocytes, immune cells and endothelial cells. This opens up new avenues for interrogating genetic elements and modeling disease directly in vivo in potentially any tissue or cell type.

Presented by: Randall J. Platt, Feng Zhang Lab, Broad Institute of MIT and Harvard Originally aired on: November 12, 2015

Other CRISPR Resources

gRNA design tool

CRISPR Handbook

Gene functional study tools

GenScript provides the tools needed to accelerate your gene functional studies including services for gene overexpression, gene knockout, and mutant clone creation.

Overexpress	Knockout	Mutate
cDNA ORF clones Expression ready Starting from $99/clone Spring promo: Take 20% off your ORF	CRISPR gRNA constructs Targeted validated gRNA constructs $199/ clone	cDNA ORF clone mutants Point mutations, insertions, deletions Starting from $149 per mutant
Search For Your ORF Clone	Search For Your gRNA Constructs	Create Your Mutant Clone

Speaker-related Webinars

Introduction to immune checkpoints – the new hot target for cancer immunotherapy

Introduction to immune checkpoints – the new hot target for cancer immunotherapy

Development of therapeutic antibodies against immune checkpoints for the treatment of melanoma and other cancers is gaining momentum among academia and the pharmaceutical industry.

Leveraging GenScript’s cytokines, antibodies, and protein purification tools to explore Ideas for your next grant

Leveraging GenScript’s cytokines, antibodies, and protein purification tools to explore Ideas for your next grant

Wouldn't it be great if all the supplies you needed to obtain preliminary data for your next grant were available from the same vendor? This webinar will show you how to incorporate

Recombinant protein applications: choosing the best cytokine, growth factor or chemokine for your experimental system

Recombinant protein applications: choosing the best cytokine, growth factor or chemokine for your experimental system

Are you treating cells in vitro? Do your in vivo studies investigate changes in the immune response or tumor growth?

Stem cell culture: choosing the best conditions for optimal expansion and differentiation

Stem cell culture: choosing the best conditions for optimal expansion and differentiation

Are you finding your rate of stem cell differentiation to be less than optimal? Choosing the appropriate conditions for stem cell expansion and differentiation is critical for obtaining a high yield of properly differentiated cells

Biologics Drug Discovery: Steps to Achieving an Antibody Drug Candidate

Biologics Drug Discovery: Steps to Achieving an Antibody Drug Candidate

In the past decade, drug discovery has focused on developing biologics. In particular, antibody therapeutics have been proven to be clinically effective for disease areas such as oncology and immunology.

Latest Webinars

Find More CRISPR Categories »

Secure Your CRISPR Pipeline with Scalable cGMP Guide RNA

Secure Your CRISPR Pipeline with Scalable cGMP Guide RNA

Revolutionizing Therapeutics and Genomic Research with Cutting-Edge mRNA Technologies

Revolutionizing Therapeutics and Genomic Research with Cutting-Edge mRNA Technologies

Self-Amplifying RNA in Vaccines and Beyond

Self-Amplifying RNA in Vaccines and Beyond