This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
The human BCL2 gene is shown in the context of the human genome below. To see information about the BCL2 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse BCL2, rat BCL2, and human BCL2, as well as on-demand BCL2 ORF clones in 183 other species.
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