The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
The human BLM gene is shown in the context of the human genome below. To see information about the BLM gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse BLM, rat BLM, and human BLM, as well as on-demand BLM ORF clones in 183 other species.
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