This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
The human MAPT gene is shown in the context of the human genome below. To see information about the MAPT gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MAPT, rat MAPT, and human MAPT, as well as on-demand MAPT ORF clones in 183 other species.
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