This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
The human SIRT1 gene is shown in the context of the human genome below. To see information about the SIRT1 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse SIRT1, rat SIRT1, and human SIRT1, as well as on-demand SIRT1 ORF clones in 183 other species.
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