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Do you need APC gene to express the APC protein for functional or characterization studies? Get the APC gene in an Expression-Ready Vector for your molecular biology studies by ordering an APC ORF Clone.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
The human APC gene is shown in the context of the human genome below. To see information about the APC gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse APC, rat APC, and human APC, as well as on-demand APC ORF clones in 183 other species.
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