About the Olfactory transduction pathway
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
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| Gene Symbol | Full Name |
|---|---|
| ADCY3 | adenylate cyclase 3 |
| ADRBK2 | adrenergic, beta, receptor kinase 2 |
| ARRB2 | arrestin, beta 2 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CALML3 | calmodulin-like 3 |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CLCA1 | chloride channel accessory 1 |
| CNGB1 | cyclic nucleotide gated channel beta 1 |
| CNGA3 | cyclic nucleotide gated channel alpha 3 |
| CNGA4 | cyclic nucleotide gated channel alpha 4 |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type |
| GUCA1A | guanylate cyclase activator 1A (retina) |
| GUCA1B | guanylate cyclase activator 1B (retina) |
| GUCY2D | guanylate cyclase 2D, membrane (retina-specific) |
| OR1D2 | olfactory receptor, family 1, subfamily D, member 2 |
| OR1F1 | olfactory receptor, family 1, subfamily F, member 1 |
| OR2C1 | olfactory receptor, family 2, subfamily C, member 1 |
| OR3A1 | olfactory receptor, family 3, subfamily A, member 1 |
| OR3A2 | olfactory receptor, family 3, subfamily A, member 2 |
| PDC | phosducin |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma |
| PRKG1 | protein kinase, cGMP-dependent, type I |
| PRKG2 | protein kinase, cGMP-dependent, type II |
| PRKX | protein kinase, X-linked |
| OR2H2 | olfactory receptor, family 2, subfamily H, member 2 |
| OR1A1 | olfactory receptor, family 1, subfamily A, member 1 |
| OR1D5 | olfactory receptor, family 1, subfamily D, member 5 |
| OR1E1 | olfactory receptor, family 1, subfamily E, member 1 |
| OR1E2 | olfactory receptor, family 1, subfamily E, member 2 |
| OR1G1 | olfactory receptor, family 1, subfamily G, member 1 |
| OR3A3 | olfactory receptor, family 3, subfamily A, member 3 |
| OR6A2 | olfactory receptor, family 6, subfamily A, member 2 |
| GUCA1C | guanylate cyclase activator 1C |
| CLCA2 | chloride channel accessory 2 |
| OR5I1 | olfactory receptor, family 5, subfamily I, member 1 |
| CLCA4 | chloride channel accessory 4 |
| OR52A1 | olfactory receptor, family 52, subfamily A, member 1 |
| OR1C1 | olfactory receptor, family 1, subfamily C, member 1 |
| OR1A2 | olfactory receptor, family 1, subfamily A, member 2 |
| OR2F1 | olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) |
| OR2B6 | olfactory receptor, family 2, subfamily B, member 6 |
| OR1J4 | olfactory receptor, family 1, subfamily J, member 4 |
| OR2M4 | olfactory receptor, family 2, subfamily M, member 4 |
| OR2L2 | olfactory receptor, family 2, subfamily L, member 2 |
| OR2K2 | olfactory receptor, family 2, subfamily K, member 2 |
| OR7A17 | olfactory receptor, family 7, subfamily A, member 17 |
| OR5L2 | olfactory receptor, family 5, subfamily L, member 2 |
| OR5K1 | olfactory receptor, family 5, subfamily K, member 1 |
| OR5H1 | olfactory receptor, family 5, subfamily H, member 1 |
| OR10J1 | olfactory receptor, family 10, subfamily J, member 1 |
| OR8G2 | olfactory receptor, family 8, subfamily G, member 2 |
| OR8B8 | olfactory receptor, family 8, subfamily B, member 8 |
| OR8G1 | olfactory receptor, family 8, subfamily G, member 1 (gene/pseudogene) |
| OR10A3 | olfactory receptor, family 10, subfamily A, member 3 |
| OR12D2 | olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) |
| OR11A1 | olfactory receptor, family 11, subfamily A, member 1 |
| OR10H3 | olfactory receptor, family 10, subfamily H, member 3 |
| OR10G3 | olfactory receptor, family 10, subfamily G, member 3 |
| OR10G2 | olfactory receptor, family 10, subfamily G, member 2 |
| OR10H2 | olfactory receptor, family 10, subfamily H, member 2 |
| OR10H1 | olfactory receptor, family 10, subfamily H, member 1 |
| OR8B2 | olfactory receptor, family 8, subfamily B, member 2 |
| OR7E24 | olfactory receptor, family 7, subfamily E, member 24 |
| OR7C2 | olfactory receptor, family 7, subfamily C, member 2 |
| OR7A5 | olfactory receptor, family 7, subfamily A, member 5 |
| OR7C1 | olfactory receptor, family 7, subfamily C, member 1 |
| OR4F4 | olfactory receptor, family 4, subfamily F, member 4 |
| OR4F3 | olfactory receptor, family 4, subfamily F, member 3 |
| OR4E2 | olfactory receptor, family 4, subfamily E, member 2 |
| OR4D1 | olfactory receptor, family 4, subfamily D, member 1 |
| OR2W1 | olfactory receptor, family 2, subfamily W, member 1 |
| OR2V1 | olfactory receptor, family 2, subfamily V, member 1 |
| OR2T1 | olfactory receptor, family 2, subfamily T, member 1 |
| OR2J2 | olfactory receptor, family 2, subfamily J, member 2 |
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 |
| OR1L3 | olfactory receptor, family 1, subfamily L, member 3 |
| OR1L1 | olfactory receptor, family 1, subfamily L, member 1 |
| OR1J2 | olfactory receptor, family 1, subfamily J, member 2 |
| CALML5 | calmodulin-like 5 |
| OR2S2 | olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) |
| OR13A1 | olfactory receptor, family 13, subfamily A, member 1 |
| OR5H6 | olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) |
| OR5H2 | olfactory receptor, family 5, subfamily H, member 2 |
| OR4K5 | olfactory receptor, family 4, subfamily K, member 5 |
| OR51G1 | olfactory receptor, family 51, subfamily G, member 1 (gene/pseudogene) |
| OR51B4 | olfactory receptor, family 51, subfamily B, member 4 |
| OR51B2 | olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) |
| OR52N1 | olfactory receptor, family 52, subfamily N, member 1 |
| OR4F5 | olfactory receptor, family 4, subfamily F, member 5 |
| OR2A4 | olfactory receptor, family 2, subfamily A, member 4 |
| OR4K1 | olfactory receptor, family 4, subfamily K, member 1 |
| OR5AC2 | olfactory receptor, family 5, subfamily AC, member 2 |
