This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The human KIT gene is shown in the context of the human genome below. To see information about the KIT gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse KIT, rat KIT, and human KIT, as well as on-demand KIT ORF clones in 183 other species.
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