Antibody-epitope mapping provides novel insight into the specific binding interactions between proteins and antibodies. Similar to T cell mapping, antigenic peptides are screened following the addition of specific antibodies. If there is binding, then the peptide can be considered as "immunogenically fit", or capable of being immunogenic and promoting passive immunity. Binding events can be monitored in a variety of quantitative or qualitative methods, one of the most common being via ELISA. This screening technique has been used to identify the most effective monoclonal antibodies to treat multiple disorders and diseases, including muscular dystrophy and Alzheimer's disease.
Nikolaeva et al. Epitope mapping for monoclonal antibodies recognizing tuber necrotic isolates of Potato virus Y. Am J Potato Res. 2012 Apr; 89(2):121-128. Read more
Armistead et al. Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria. Infection and Immunity. 2014 Feb; 82(2): 818-829. Read more
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