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Scrambled Library
Scrambled Library
A scrambled library has the highest variation of any peptide library. The library is constructed through sequence permutation of the original peptide. Representing all possible alternative peptides, the scrambled library creates an ideal scenario for sequence optimization. It can be used to probe target molecules of interest including proteins, antibodies, and DNA.
Applications Of Scrambled Library
- Screening proteins of interest
- Negative controls
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References
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- Murayama O, Nishida H, and Sekiguchi K. Novel peptide ligands for integrin alpha 6 beta 1 selected from a phage display library. J. Biochem. Aug 1996; 120(2): 445-51.
- Keizer DW, Miles LA, Li F, Nair M, Anders RF, Coley AM, Foley M, and Norton RS. Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion. Biochemistry. Aug 2003; 26; 42(33): 9915-23.