Scientists take many approaches to design vaccines against a pathogenic microorganism. These choices are dictated by the nature of pathogen and the infection as well as practical considerations about the use of the vaccine. Some of the options include live attenuated vaccines, inactivated vaccines, DNA vaccines and recombinant subunit vaccines. See schematic below for an overview of the various approaches used to make a vaccine. This technical note discusses the basics of research and production of recombinant vaccines.
Figure 1: Various approaches for Vaccine Development