CellPower™ Cell Line Development

Overview

Cellular assays, also known as stable cell-based assays, serve as invaluable tools in biomedical research and drug-discovery screenings. They efficiently quantify cytotoxicity, assess biological activity, investigate biochemical mechanisms, and study off-target interactions. Cell-based assays offer distinct advantages, as they generate complex and biologically relevant data, providing a more physiologically meaningful assessment compared to traditional biochemical assays. These assays have the ability to simultaneously evaluate multiple compound characteristics.

GenScript offers a stable cell line service that leverages our extensive expertise in both protein expression and cell line engineering, with over 19 years of experience in protein expression. Our team of Ph.D.-level experts provides technical support for all your projects. While we encourage customers to supply their own cell lines, GenScript also offers available cell lines for purchase at an additional cost. Please note that, at this time, we do not provide genome editing services for primary cells, stem cells, or iPS cells. For validation services related to assay cell lines, please refer to the "Add On Services" tab.

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250+ cells delivery

Extensive proteins experience

PhD Experts support

Workflow

Service Specifications

• Our cell line service is only applicable for in vitro works.
• Please note that we do not offer genome editing for primary cells, stem cells, or iPS cells at this time. Validation services for CRISPR cell lines can be accessed through the "Add On Services" tab.

Add-On Service

Case Study

• Therapeutic Anti-Claudin 18.2 Drug Lead Screening

  Customer requirement: Generation therapeutic anti-Claudin18.2 antibodies

  • Claudin 18.2: Tetra-Transmembrane, Gastric tumor marker
  • Claudin 18.1: Alternatively Spliced, Rich in lung tissue

  Project Goal:

  • To develop Cell Lines expressing Claudin 18.2 or 18.1
  • Use these Cell Lines as immunogen for monoclonal antibody development and screening purposes

  Antigen preparation

  Immunization

  Hybridoma Formation

  Hybridoma Screening

  Validation

  Cell lines	Application	Purpose
  CHO-K1/human Claudin18.2	Antigen	Immunization
  HEK293/human Claudin18.2	Hybridoma screening	Positive screening
  HEK293/human Claudin18.1	Hybridoma screening	Negative screening
  HEK293 parental	Hybridoma screening	Negative screening

  

Resources

• CRISPR Webinar
  Dr. Theo Roth from Marson Lab, UCSF

  introduces the advantages of a new CRISPR based method that allows for the insertion of large DNA sequences (>1Kb) in primary T cells without a virus.

  Learn More
• White Paper
  

  CRISPR Handbook

  Enabling Genome Editing and Transforming Life Science Research

  Free Download

  

  Protein Service Handbook Protein Service Handbook

  The Valuable Guide for Your Cell Engineering Research.

  Free Download Free Download

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