Peptide drugs are a rapidly growing class of therapeutics. However, the peptide drug discovery has been hampered by its inherent characteristics: low stability due to susceptibility to enzymatic digestion, low target specificity because of high conformational flexibility, low hydrophobicity and the lack of specific transportation systems. In order to overcome these disadvantages of peptide, GenScript has developed an innovative Peptoid Synthesis (SC1559) service to meet the increasing needs in drug target discovery and lead structure discovery research.

Peptoids, or poly-N-substituted glycines, are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone rather than to the α-carbons (as they are in amino acids). In native peptides, R group represents 20 different substitutions for specific amino acids, while in peptoids, the selection of R groups can be much wider and potentially unlimited.

peptoid vs peptide

Fig.1 Structural comparison between peptide and peptoid


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