Resources » Reference Databases » Citations Database

For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate.

Mem. Inst. Oswaldo Cruz. 2018; 
GabrielHeloisa B，AzevedoMauro F，KimuraEmília A，KatzinAlejand
Products/Services Used Details Operation
Gene Synthesis … For the plasmid construction, the FPPS/GGPPS coding sequence (PlasmoDB ID: PF3D7_1128400) was synthesised by GenScript, and FPPS/GGPPS was cloned in pRM2-GFP-HA-DD24, 19 replacing the GFP gene with the XhoI/MluI restriction site to generate pRM2-FPPS … Get A Quote

Abstract

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate， a bisphosphonate containing nitrogen (N-BP)， is a potent inhibitor of blood stage Plasmodium. Here， we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate， suggesting that this enzyme is an important target， and bisphosphonate analogues can be used as potential antimalarial drugs.

Keywords

Article Link >

Most Popular Services

Homology-Directed Repair (HDR) Knock-in Templates
CRISPR Cas9 Single guide RNA (sgRNA) and Ribonucleoprotein (RNP)
Plasmid DNA Preparation Service
Mammalian CHO Expression Service