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Generation of antibody-based therapeutics targeting the Idiotype of B-cell Malignancies.

Antib Ther. 2019-01; 
WeissEmily, SarnovskyRobert, HoMitchell, AronsEvgeny, KreitmanRobert, AngelusEvan, AntignaniAntonella, FitzGeraldD
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Catalog Antibodies … by DNA synthesis (Blue Heron Biotech), and include an OmpA periplasm directing signal sequence (cleaved upon entry in the periplasm), followed by a FLAG tag epitope (DYKDDDDK) to allow binding to an anti-FLAG affinity purification resin (Genscript catalog #L00432), the … Get A Quote

Abstract

A feature of many B-cell tumors is a surface-expressed immunoglobulin (sIg). The complementarity determiningregions (CDRs)of the sIg， termed the 'idiotype'， are unique to each tumor. We report on a phage selection strategy to generate anti-idiotype therapeutics that react with sIg CDR3 sequences: the MEC1 B-cell tumor line was used as proof of concept.

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