Preclinical Grade Plasmid DNA Preparation
GenScript offers preclinical grade plasmids with the most comprehensive and stringent quality specifications and analysis for your preclinical project needs. Ideal for preclinical in vivo animal studies, from mice to non-human primates, in gene therapy, cell therapy, and vaccine research. Available in quantities of 10 mg and up.
Comprehensive Quality Control
✔ Highly homogenous (≥90% supercoiled)
✔ Endotoxin free (≤0.005 EU/μg)
✔ Quantitative bacterial DNA & protein analysis
✔ Plant based culture media
✔ Enzyme-free chromatographic purification
✔ TSE/BSE Certificate
Guaranteed Quantity
✔ From mg to multi-gram level
✔ High density fermentation
✔ Material archiving
| QC Items | Analytical Method | Specification | |
|---|---|---|---|
| Default QC Items | Appearance | Visual inspection | Clear, colorless, no visible particulates |
| A260:280 | Nanodrop UV absorption | 1.8-2.0 | |
| Identity | Sequence verification of full gene insert | 100% alignment with reference sequence | |
| pH | pH meter | 8.0±0.5 (in TE buffer) | |
| Restriction Analysis | Enzyme digestion and electrophoresis | Conforming to reference pattern | |
| Homogeneity | Agarose gel electrophoresis | ≥ 90% supercoiled | |
| Endotoxin | Quantitative LAL assay | ≤ 0.01 EU/μg | |
| Residual E. coli DNA | Quantitative PCR | ≤ 5% | |
| Residual RNA | Agarose gel electrophoresis | Non-detectable at 200ng | |
| Residual Host Protein | HCP ELISA | ≤ 1% | |
| Bioburden Testing | Direct incubation | No growth on agar plate after 48 hours | |
| Add-On QC Items | Advanced Endotoxin Removal | Quantitative LAL assay | ≤ 0.005 EU/μg |
| Mycoplasma Contamination | Luminescence detection kits | Negative | |
| Detection of Kanamycin | ELISA | ＜1.125 ng/ml |
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