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Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.

J. Neurosci. Methods. 2015; 
StenslikMallory J，PottsLisa F，SonneJames W H，CassWayne A，Turchan-CholewoJadwiga，PomerleauFrancois，HuettlPeter，AiYi，GashDon M，GerhardtGreg A，BradleyLu
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Abstract

To circumvent the challenges associated with delivering large compounds directly to the brain for the treatment of Parkinson's disease (PD)， non-invasive procedures utilizing smaller molecules with protective and/or restorative actions on dopaminergic neurons are needed.

Keywords

6-Hydroxydopamine，Intranasal administration，Neurochemistry，Neuroprotection，Nigrostriatal pathway，Pep
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