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Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.

Mol Nutr Food Res. 2011; 
Granados-PrincipalSergio，QuilesJose L，Ramirez-TortosaCesar，Camacho-CorenciaPedro，Sanchez-RoviraPedro，Vera-RamirezLaura，Ramirez-TortosaM Ca
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Protein and Antibody Isolation … 2.5 Apoptosis detection. Sections of mammary tumour tissue were stained using the terminal deoxynucleotidyl transferase (TdT) dUTP‐nick‐end labelling (TUNEL) method using a commercial apoptosis detection kit (Genscript, NJ, USA) … Get A Quote

Abstract

Hydroxytyrosol (a phenolic compound derived from virgin olive oil) has demonstrated an anti-tumour effect in several tumour cell lines in addition to other health-related properties. The aim of this study was to investigate， for the first time in an animal model of experimental mammary carcinoma， the anti-cancer ability of hydroxytyrosol and to discover which pathways are modified by hydroxytyrosol.

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