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The overall discovery process for Ab therapeutics can be broadly divided into five
Often time, screening, hit generation & lead selection are also collectively referred to
as “Lead Discovery”. Activities leading up to the selection of the clinical candidate
are referred to as “preclinical” work/research. While the language and choice of
words changes from one publication to another, the concept remains the same.
Figure 1: Overview of discovery process for therapeutic antibodies leading to the selection of a clinical candidate is shown in the workflow above. Key activities at each of the five stages are listed in the text boxes.
The answer is that it depends on the target. Small molecules penetrate the cell whereas large molecules (Ab therapeutics) typically target cell surface molecules like receptors
or tumor antigens. And hence research will dictate what kind of intervention is
required in a particular disease pathway. See major differences between small
molecule and large molecule research in the table below.
Table 1: Small molecule drugs vs large molecule drugs.
The previous section in this series is “Antibody Formats”. To review, click here.
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