GenCRISPR® Cas9 Genome Editing Products
CRISPR/Cas9 technology is a powerful technique that has revolutionized the field of sequence-specific gene editing due to it's high precision, simplicity and flexibility. The CRISPR/Cas9 system consists of two major components: the Cas9 nuclease and the sequence-specific guide RNA (gRNA). They can form a very stable ribonucleoprotein (RNP) complex. Once a specific DNA region is matched by the gRNA carrying Cas9, the target DNA is cleaved with a double stranded break. Cas9 RNP complex can be introduced into cells directly and act immediately after it enters the cell without transcription and translation. By matching the gRNA sequence with different functional domains, the CRISPR/Cas9 system and its variants have been used for a broad range of gene editing applications (knock-out, knock-in, gene up/down, genome purification and visualization et. al.).
GenScript offers multiple kits to assemble your own Cas9 and gRNA constructs, as well as purified Cas9 enzymes for in vitro and in vivo use.
Cas9 enzymes
- Cas9 nuclease
- Cas9-D10-nickase
- Cas9-EGFP
Gene editing kits
- gRNA synthesis
- gRNA activity screening
- Mutation detection kit
Cas9 antibodies
- SpCas9 (mAb Rb, mouse)
- SaCas9, StCas9
- FnCpf1, AsCpf1, LbCpf1
CRISPR/Cas9 Plasmids
- All-in-one or dual SpCas9, Nickase & SaCas9
- Constructs for gRNA expression
- SAM constructs for transcription activation
CRISPR RNAs
- Synthetic Cas9 crRNAs
- Synthetic Cas9 tracrRNAs
CRISPR Libraries
- GeCKO libraries for genome-wide knock-out
- SAM libraries for genome-scale transcription activation
