Cas9 Nucleases for CRISPR Research and Clinical Applications

GenCRISPR™ Cas9 proteins are optimized for high CRISPR editing efficiency across various gene targets and cell types. Research shows protein delivery is superior to mRNA and DNA forms. When combined with guide RNA (gRNA), these ribonucleoprotein (RNP) complexes bypass transcription and translation, boosting efficiency. GenScript offers a range of Cas9 proteins, including GenCRISPR™ SpCas9, GenCRISPR™ Ultra eSpCas9, and GMP-grade Cas9.

Cas9 Nuclease Comparison Table


GenCRISPR™ SpCas9

Wild-type Cas9 protein engineered for optimal CRISPR editing performance

Applications: Suitable for a wide range of CRISPR gene editing experiments.


GenCRISPR™ Ultra eSpCas9

High-fidelity Cas9 variant engineered for enhanced specificity without compromising efficiency

Applications: Ideal for CRISPR experiments that need precise editing or low off-target effects.


GMP-grade GenCRISPR™ SpCas9 and Ultra eSpCas9

Wild-type and high-fidelity Cas9 produced to meet the requirements for clinical development

Applications: Ideal for CRISPR projects that aim for therapeutic applications.

GenCRIPSR™ SpCas9

  • High knockout and knock-in efficiency
  • Approved in 7 IND applications
  • Equivalent or better performance than the leading suppliers
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GenCRISPR™ SpCas9 Product Data

GenCRIPSR™ Ultra eSpCas9 (mt)

  • Extremely low off-target effects
  • Comparable on-target editing efficiency
  • Licensed from Dr. Feng Zhang’s Lab at Broad Institute
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GenCRISPR™ Ultra eSpCas9 Product Data

GMP-Grade Cas9 Proteins for ex vivo Cell Therapy

For the seamless transition from research to clinical practice, high-quality materials and thorough documentation are essential. GenCRISPR GMP-grade Cas9 proteins are crafted to strict standards to aid in your cell therapy development projects.

Can’t find what you need?

In addition to our catalog of Cas9 products, GenScript provides customized CRISPR Cas Nuclease services. We can produce nucleases for a variety of CRISPR systems, including MAD7, Cas12a, Cas13, and Cas-mini to base editor/prime editor configurations. For more details, visit our custom CRISPR Cas Nuclease page or fill out the contact form.

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