Custom Peptide Synthesis Enables
Your Downstream Applications

Chemical synthesis technologies have significantly facilitate the study of biological sciences in many areas. Differentiated from the biological synthesis widely used in recent decades, the chemical synthesis has over 100 year history and made huge contributions to the industrial development and energy shortages. Thanks to the cutting-edge technologies, reagents and reaction devices, chemical synthesis process new can produce various amounts from mg to tons products. The structure of these synthesized products can be natural or artificial designed to meet the different purposes like new materials and medical molecules. With the fast development in biological and biomedical fields, peptides play more and more important roles in the research pipeline. For instance, it can be worked as antigen to immune animals when generating antibodies. Peptide also can be used to study protein-protein interactions when conducting function assay. By taking the advantage of small molecular weight, peptide drugs (i.e., neoantigen and antimicrobial peptide) and cosmetic peptides are becoming more and more popular.

For all these researches, the success of peptide synthesis and high quality are the top concerns when our scientists seek for reliable industrial collaborators. GenScript is indeed listed in the top of your list. GenScript is able to provide peptides of 100% guaranteed quantity from mg to kg at industry-leading speed. In addition to 17+ experience in chemical synthesis of custom peptide synthesis, 300+ modifications are available to meet various requests, and proven track record showed the length up to 200 AA as well.

In addition, free toolbox is available to facilitate your design. Peptide Analyzing Tool was developed to help evaluate the feasibility of all peptide sequences prior to synthesis. And OptimumAntigen Design Tool was geared up with well validated algorithms to shape your peptide antigen design.

Benefits of Custom Peptide Synthesis

Who Will Need Custom Peptide Synthesis

Peptides have been successfully used in many fields, such as vaccine development, drug discovery and therapeutics development, antibody generation, tissue engineering materials, cancer therapy and cosmetic components.

Featured Applications of Custom Peptide Synthesis

Precision Personalized Treatment

Neoantigens are immunogenic peptides generated by tumor-specific mutation, and can be used as the biomarker to distinguish cancer cells from normal ones. Due to the high specificity of expression and low tolerance of induction, it can be deployed as target of tumor immunotherapy. Up to date, it has been widely used in the therapy study in melanoma, breast cancer and lung cancer, etc. Neoantigen peptide can be used for the study of neoantigen precision immunotherapy from functional screening of neoantigen candidates for TCR therapy to clinical stage vaccine immunogenicity testing.

Tissue Engineering Materials

Some macromolecular peptides (polyaspartic acid, polylysine, and polyglutamic acid) are not biologically active, while they are excelled in many properties, including biocompatibility, controllable biodegradation rate, modifiability, plasticity, etc. Thus, they have gradually become a new type of material for tissue engineering. Researchers prepared poly(lactic acid-lysine) and grafted RGD peptide to the -NH2 of lysine in the polymer, which effectively improved the cell adhesion ability on the polymer surface and overcome the inactive groups of the main chain. The newly created tissue engineering scaffold material is not only convenient for cell identification, but also can support cell growth. In addition, in 2019, another research group developed a novel tissue generating peptide with the ability to transform stem cells to bone cells in a 3D-printed artificial bone scaffold, which gives great insight into bioactive implant technologies for clinical applications in tissue regeneration. Learn More »

Explore Free Resources for Custom Peptide Synthesis

Poster: Novel Technologies for Difficult Neoantigen Peptide Synthesis

How to improve the synthesis success rate of difficult peptides used as neoantigen is critical for personalized immunotherapies. GenScript has explored proprietary NeoPre algorithm to identify synthetic difficulty and recommend the best synthetic technology based on each individual peptides intrinsic characteristics. Learn More »

Application Note: Identifying COVID-19 Vaccine Epitopes Using Peptide Based T cell Activation Assays

White Paper: Why do TFA residues from custom peptide synthesis matter for downstream experiments?

When employing Fmoc-protected strategy for custom peptide synthesis, trifluoroacetic acid (TFA) is used to cleave the peptide from the resin support, and is added in the mobile phase for a better separation in purification. TFA residues in the custom peptides may cause unpredictable fluctuations in the experimental data. The upper limit of TFA concentration varies in different researches. Learn More »

Tips

Peptide purity will affect experimental results since the lot-to-lot variability becomes even greater the lower the peptide purity is (especially <80% purity). How to select proper purity to meet your downstream applications? Learn More »

Webinar: Neoantigen immunopeptidome profiling and production for personalized immuno-oncology therapeutic discovery

The experts will review the use of neoantigen peptides in personalized cancer treatment and share techniques for predicting and producing difficult neoantigen peptides. Learn More »

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